FPGEE for National Association of Boards of Pharmacy (NABP) Practice Exam

Which quality control test is NOT typically required for ointments or creams?

1. pH measurement

2. Testing dissolution characteristics

3. Physical observation for clarity

4. Theoretical weight comparisons

The correct answer is: Testing dissolution characteristics

The focus of this question is to identify which quality control test is not typically required specifically for ointments or creams. Testing dissolution characteristics is primarily associated with solid dosage forms, such as tablets and capsules, where the rate at which the drug dissolves in a specific solvent is crucial for its bioavailability. Ointments and creams, being semi-solid formulations, are evaluated with other quality control tests that ensure their stability, effectiveness, and patient usability. For instance, pH measurement is essential as it influences the drug's stability and the skin's absorption. Physical observation for clarity is also important, as it assesses the visual quality of the product, ensuring there are no particulate matters or cloudiness that could affect its reliability. Theoretical weight comparisons validate the content uniformity and confirm that the formulation contains the intended amount of active ingredients. In conclusion, testing dissolution characteristics does not apply to ointments or creams since these formulations do not undergo dissolution in the same manner as solid dosage forms. Instead, quality control for these products revolves around other parameters that confirm their intended performance and safety for use.