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Which of the following is NOT a common levigating agent?
Glycerin
Water
Sodium chloride
Propylene glycol
The correct answer is: Sodium chloride
Levigating agents are substances used to help in the process of breaking down solids into smaller particles, often to create a homogenous mixture in compounded formulations. Common levigating agents, such as glycerin, water, and propylene glycol, are utilized due to their compatibility with various drug formulations and their ability to aid in achieving a smooth, uniform texture. Sodium chloride is primarily known for its use as a saline solution or electrolyte in various applications but is not typically employed as a levigating agent. It does not have the same properties as the other agents listed, which can effectively disperse solid materials and reduce particle size in the preparation of ointments, creams, and other compounded products. The primary role of sodium chloride does not align with the function of promoting wetting and uniformity in solid dispersions needed for effective levigation. Understanding these roles of common levigating agents helps clarify why sodium chloride is not suitable for this purpose while the other options are frequently used in pharmaceutical preparations.